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Why You Should Probably Be Using a Vitamin C Serum, According to Dermatologists

In theory, almost everyone can incorporate a vitamin C serum into their skincare routine. However, Dr. Marmur cautions that too much vitamin C can potentially irritate skin. It depends on your skin type, but she personally recommends products that contain between 10 to 15% potency for best results.

Vitamin C is highly effective in its pure form, according to Wnek, but it is a tricky ingredient to formulate with because it is very unstable and can degrade with exposure to oxygen, light, water and high pH. That means that while it is a hero ingredient, its properties are difficult to stabilize — and because of that, some vitamin C serums and other skincare products work better (and for longer) than others.

✔️ If you have dry skin, you might want to look for added moisturizing ingredients like hyaluronic acid.

✔️ If you have oily skin, look for “ascorbic acid” on the label rather than the oil soluble “ascorbyl palmitate.”

✔️ If you have very sensitive skin or rosacea, know that your skin is already compromised, so using a vitamin C serum can possibly cause irritation and you may want to steer clear.

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This Drugstore Face Serum Measurably Firmed Skin in Lab Testing

To find the best face serum for you,”choose a formula that is appropriate for your skin type and texture, as well as the outcomes you want to achieve,” Dr. Mitchell advises. Here are the GH Beauty Lab and dermatologists’ general guidelines:

✔️ For glowing skin: Seek out brightening and exfoliating ingredients like vitamin C, niacinamide and glycolic acid. “Vitamin C is a great option for those looking for more luminous skin and can reduce the appearance of uneven skin tone and hyperpigmentation,” Dr. Zenovia says.

✔️ For dry skin: Ingredients like hyaluronic acid, vitamin E and ceramides are great “hydrating components that absorb easily into skin,” Dr. Mitchell says. Squalane is another effective hydrator, adds Dhaval G. Bhanusali, M.D., dermatologist and founder of Hudson Dermatology and Laser Surgery in New York City.

✔️ For anti-aging and wrinkles: Dermatologist go-to’s for smoothing lines and reducing age spots include retinol, peptides and glycolic acid. “Bakuchiol is a newer ingredient that also can provide benefit and is generally well-tolerated,” Dr. Bhanusali says. In addition, “antioxidants, including vitamins (C, E, and B3 or niacinamide), polyphenols, and flavonoids, slow the breakdown of collagen by lowering the concentration of free radicals in your skin,” Dr. Mitchell notes.

✔️ For sensitive skin: Choose serums made without fragrance, which can irritate. Opt for those made with hydrating ingredients (hyaluronic acid, vitamin E, ceramides) “to repair the skin’s barrier,” Dr. Zenovia says, and/or soothers such as oat extracts, aloe, green tea and chamomile.

✔️ For oily skin: Dr. Bhanusali recommends the active ingredients salicylic acid and niacinamide, which can help reduce excess oil.

✔️ For acne-prone skin: “Salicylic acid and glycolic acid can help clear pores” and minimize breakouts, Dr. Mitchell says.

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Why You Need an Antioxidant Serum for Younger-Looking Skin

antioxidant serums

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We updated this article in December 2022 to add more expert commentary and information about each featured product, plus three new picks from Mary Kay, Olay and SkinCeuticals based on extensive testing done by the Good Housekeeping Institute.


You may have heard of antioxidants in your food — but they’re also a key part of an effective skincare routine for any skin type. Antioxidants, like vitamin C and resveratrol, play a crucial role in just how healthy, radiant and youthful your face looks both now and over time. “Every day, we are exposed to environmental factors that create free radicals in our skin, like pollution and ultraviolet rays,” explains Kavita Mariwalla, M.D., a dermatologist in West Islip, New York.

That’s where antioxidants, both in the form of ingested nutrients and in topical skincare products like face serums, come in. Applying skincare made with antioxidants an help neutralize the damaging effects of free radicals, says Dendy Engelman, M.D., a dermatologist in New York City — and, over time, help prevent and repair signs of skin aging, including hyperpigmentation, lines and wrinkles, inflammation and dullness.

In the Good Housekeeping Institute Beauty Lab, our scientists have a long history of testing face serums, including antioxidant and anti-aging serums, using scientific instruments to measure changes in skin over the time period of product use. Consumer testers also evaluate formulas on factors like the appearance of their skin before and after use, plus the product’s ease of use and cosmetic attributes. This data is then collated to find the best serums, including those with antioxidant properties.

Our top picks:

Not all antioxidant serums are created equal — some have bonus benefits like wrinkle smoothing, brightening, calming and more, depending on your skin type and needs. Here, read all about the best antioxidant serums you can buy and their benefits, including GH Beauty Lab top-tested formulas and Good Housekeeping Seal star picks, plus more on the top ingredients to look for.

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1

Best Overall Antioxidant Serum

Mary Kay

TimeWise Replenishing Serum C+E

Main ingredients Vitamins C and E
Additional benefits Firming, brightening, line smoothing
Size 1.5 oz.
2

Best Value Antioxidant Serum

RoC

Multi Correxion Revive + Glow Vitamin C Serum

Main ingredients Vitamin C, peptides
Additional benefits Brightens, evens skin tone
Size 1 oz.
3

Best Antioxidant Serum for Sensitive Skin

Eau Thermale Avène

A-Oxitive Antioxidant Defense Serum

Main ingredients Vitamins C and E, hyaluronic acid
Additional benefits Calming, softening
Size 1 oz.
4

Best Anti-Aging Antioxidant Serum

No7

Protect & Perfect Intense Advanced Serum

Main ingredients Vitamins C and E, peptides, retinol, hyaluronic acid
Additional benefits Smoothing, firming, pore minimizing
Size 1 oz.
5

Best Vitamin C Antioxidant Serum

SkinCeuticals

C E Ferulic

Main ingredients Vitamins C and E, ferulic acid
Additional benefits Brightening, anti-aging
Size 1 oz.
6

Best Antioxidant Serum for Acne-Prone Skin

SkinCeuticals

Phloretin CF Serum

Main ingredients Vitamin C, ferulic acid, phloretin
Additional benefits Evens skin tone
Size 1 oz.
7

Best Brightening Antioxidant Serum

Olay

Vitamin C + Peptide 24 Brightening Serum

Main ingredients Vitamin C, niacinamide
Additional benefits Reduces hyperpigmentation, anti-aging
Size 1.3 oz.
8

Best Antioxidant Serum for Oily Skin

SkinCeuticals

Silymarin CF

Main ingredients Vitamin C, salicylic acid
Additional benefits Purifying, smoothing
Size 1 oz.
9

Best Antioxidant Serum for Mature Skin

Mary Kay

Clinical Solutions C + Resveratrol Line-Reducer

Main ingredients Vitamin C, resveratrol, peptides
Additional benefits Anti-aging, line-smoothing
Size 0.5 oz.
10

Best Antioxidant Serum for Dark Spots

Olay

Tone Perfection Serum Vitamin B3 and Vitamin C

Main ingredients Vitamin C, niacinamide
Additional benefits Reduces hyperpigmentation, evens skin tone
Size 1.3 oz.
11

Best Dermatologist-Recommended Antioxidant Serum

SkinCeuticals

Metacell Renewal B3

Main ingredients Niacinamide, peptides
Additional benefits Line minimizing, brightening, firming
Size 1.7 oz.
12

Best Soothing Antioxidant Serum

Ren Clean Skincare

Evercalm Redness Relief Serum

Main ingredients Beta-carotene, vitamin E, hyaluronic acid
Additional benefits Calming, redness reducing
Size 1.02 oz.
13

Best Antioxidant Serum for Wrinkles

Olay

Regenerist Miracle Boost Concentrate

Main ingredients Niacinamide, peptides
Additional benefits Line smoothing
Size 1 oz.

How we test antioxidant serums

To determine the best serums, including those with antioxidants, GH Beauty Lab scientists first label-mask the products to eliminate bias, then distribute them to dozens of consumer testers, who use the formulas in their daily routines over a set time period between four and twelve weeks. In the Lab, analysts use the Visia Complexion Analyzer device to track changes in skin during the product’s use, including hyperpigmentation, lines and wrinkles, and pores.

When applicable, the Cutometer machine (below), which gauges skin laxity, is used to measure changes in firmness. Testers also report their feedback on skin’s look and feel during and after use, perceived changes in skin, and product attributes such as ease of use, scent, texture and absorption. Hundreds of data points are then tallied to find the best serums to target specific skincare issues.

What to look for when shopping for the best antioxidant serum

Although many ingredients are touted for their antioxidant effects, these are the most proven effective actives to seek out in face serums, according to Dr. Mariwalla:

✔️ Vitamin C, also known as ascorbic acid, known for reducing hyperpigmentation and evening skin tone. It’s the gold standard of antioxidants and is best for combination or dry skin, but steer clear if you’re oily or acne-prone, says Dr. Mariwalla, since “vitamin C does make some people break out.”
✔️ Niacinamide, a form of vitamin B3, has added benefits including brightening, minimizing wrinkles, and strengthening the skin barrier to lessen dryness and irritation. It’s generally well-tolerated by combination, dry and sensitive skin types, and is also great for acne-prone or oily skin as well.
✔️ Resveratrol, a polyphenol found in the skin of red grapes that has anti-aging effects, boosting firmness and smoothing. It’s great for combination, dry or sensitive skin.
✔️ Vitamin E, also known as tocopherol, which can soothe skin, making it ideal for combination, dry or sensitive skin.
✔️ Retinol, a vitamin A derivative, also a wrinkle smoothing and skin tone-evening active. Dr. Mariwalla recommends sticking with retinol if you’re acne- or oil-prone.
✔️ Green tea, a botanical that has anti-inflammatory effects, is best for combination, dry or sensitive skin.

What are the benefits of an antioxidant serum?

Antioxidant serums protect skin from damaging free radicals, helping prevent and repair signs of aging. “A free radical is a molecule with an unpaired electron, which means it is unstable and highly reactive,” says Dr. Mariwalla. “Free radicals on the skin are unstable atoms and as such are always seeking that extra electron from other cells to become stable,” she explains. “Once a free radical takes an electron from another molecule, that molecule becomes a free radical, setting off a chain reaction resulting in oxidative stress, which breaks down skin’s collagen and results in wrinkling and a sallow appearance. As these accumulate, the body is affected in the form of illness and accelerated aging.”

Like skin superheroes, antioxidants bind to free radicals and donate their electrons, stopping free radicals from stealing electrons from skin cells and causing damage. Over time, reduced free radical damage means less lines and wrinkles, hyperpigmentation and inflammation, which can lead to smoother and brighter skin.

When should you starting using an antioxidant serum?

Everyone’s skin is constantly exposed to free radicals, so an antioxidant serum can be beneficial at nearly any age, starting in the 20s. To incorporate an antioxidant serum into your skincare routine, apply it as your first step after washing your face in the morning, evening or both, “that way it [sits] directly on your skin,” Dr. Mariwalla advises.

If you choose to use your serum once daily, opt for the morning, since during the day skin is more exposed to environmental factors like UV light that can cause free radical damage. Note that antioxidant serums should be used in addition to a broad-spectrum face sunscreen, not in place of one.

Why trust Good Housekeeping?

April Franzino, the Beauty Director at Good Housekeeping, has over 15 years of experience researching, writing and editing skincare-related content, utilizing the expertise of GH Beauty Lab scientists and top industry professionals such as dermatologists and aestheticians. For this piece, she reported on the research behind, testing protocols for and results of the GH Beauty Lab’s testing of serums containing antioxidants. Franzino also interviewed dermatologist experts for insights into antioxidant serums as a category.

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This Hydrating Hyaluronic Acid Serum Is Your Skincare Savior This Winter

Best Hyaluronic Acid Serums

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We updated this article in November 2022 to add more information about each featured product, based on extensive testing done by the Good Housekeeping Institute. Our top-rated picks, selected by the Beauty Lab, include new additions from Olay, RoC and Mary Kay.


Consider hyaluronic acid serums the tall glass of water of skincare. Praised for its moisturizing benefits, hyaluronic acid (a.k.a. HA) comes in a variety of skincare products. Often listed as sodium hyaluronate on product ingredient lists, its effects prove both immediate and long-term. “The ingredient conditions skin and works as a humectant that draws moisture into skin,” says Good Housekeeping Institute Senior Chemist Sabina Wizemann. “It helps combat dryness and [dull skin], and restores suppleness.”

Though a gold standard ingredient for hydrating dry skin, hyaluronic acid can work on all skin types, from oily skin to sensitive skin. In narrowing down the greatest options out there, we rounded up our Beauty, Health & Sustainability Lab’s top-tested picks, plus ones that GH staffers and dermatologists use in their own routines. Just a dropper away, give skin its first defense against dryness with the best hyaluronic acid serums, below.

Our top picks:

You can read more about how we evaluate hyaluronic acid formulas in our Lab and consumer tests — plus everything you need to know to shop for your perfect formula — at the end of this guide.

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1

Best Overall Hyaluronic Acid Serum

Clinique

Smart Custom Repair Serum

2

Best Value Hyaluronic Acid Serum

The Ordinary

Hyaluronic Acid 2% + B5

3

Best Replenishing Hyaluronic Acid Serum

Isdinceutics

Hyaluronic Concentrate

4

Best Hyaluronic Acid Serum for Sensitive Skin

Ghost Democracy

Floodgate Hyaluronic Acid Serum

5

Best Moisturizing Hyaluronic Acid Serum

Boots

Ingredients Hyaluronic Acid Serum

6

Best Drugstore Hyaluronic Acid Serum

No7

Protect & Perfect Intense Advanced Serum

7

Best Hyaluronic Acid Serum With Retinol

RoC

Derm Correxion Fill + Treat Advanced Retinol Serum with Hyaluronic Acid

8

Best Hyaluronic Acid Serum for Oily Skin

Neutrogena

Hydro Boost Hydrating Hyaluronic Acid Serum

9

Best Hyaluronic Acid Serum Capsules

RoC

Multi Correxion Hydrate + Plump Night Serum Capsules

10

Best Anti-Aging Hyaluronic Acid Serum

No.7

Restore & Renew Face & Neck Multi Action Serum

11

Best Hyaluronic Acid Serum With Peptides

Mary Kay

Clinical Solutions HA + Ceramide Hydrator

12

Best Hyaluronic Acid Serum for Dewy Skin

Olay

Hyaluronic + Peptide 24 Serum

13

Best Hyaluronic Acid Serum for Dry Skin

Vichy

Mineral 89 Hyaluronic Acid Face Serum

14

Best Hyaluronic Acid Serum With Vitamin C

OLEHENRIKSEN

Truth Vitamin C Serum

15

Best Hydrating Hyaluronic Acid Serum

SkinMedica

HA5 Rejuvenating Hydrator

How we chose the best hyaluronic acid serums

Like other face serums we’ve tested, our chemists evaluated hyaluronic acid formulas based on laboratory and consumer tests. We use technical instruments in our Beauty Lab to measure skin changes — such as moisturization, elasticity, wrinkles and pores — after product use. To see how it works on different skin types in real life, our consumer testers try products out and give feedback on their ease of use. Other top-tested picks above, like Seal holders, underwent rigorous evaluation by our scientists who verified product claims. We also included everyday favorites from our GH staffers who struggle with dry or sensitive skin and use hyaluronic acid regularly.

What to consider when shopping for the best hyaluronic acid serums

✔️Keep an eye on concentration: Most hyaluronic acid formulas offer a concentration of 2% or less. “Using concentrations greater than 2% can negatively impact the skin, pulling water out of the skin [and] creating dryness,” Dr. Mack says.

✔️Do double-duty: Pairing well with other skincare ingredients, hyaluronic acid can help reduce side effects such as irritation from ingredients like vitamin C and retinol, according to Dr. Mack.

✔️Cater to your skin type: If you have a drier skin type, Dr. Mack recommends using HA serums twice a day, prior to applying moisturizer — dry skin can benefit from that added boost of hydration. For normal to combination skin types, apply nightly following a retinoid to help soothe any sensitivity.

What do hyaluronic acid serums do for your skin?

Hyaluronic acid can also have anti-aging effects, thanks to its skin-plumping properties. “It acts like a sponge that absorbs water, adding volume to skin,” Dr. Gohara says. Serums, which are lighter weight in texture than face moisturizers like lotions or creams, deliver the hydrating benefits of hyaluronic acid without heaviness and can be layered underneath other leave-on skincare products morning, evening or both.

Why trust Good Housekeeping?

We tapped Senior Chemist Sabina Wizemann for our Beauty Lab’s top-tested picks, included above. For almost a decade at GH, she’s researched, tested and evaluated thousands of products, while also verifying product claims based on her extensive knowledge of skincare ingredients. Collaborating closely with our Institute experts, Beauty Director April Franzino oversees all beauty content at GH. She spearheads our Beauty Awards and regularly writes science-backed roundups. Having dry skin herself, she wrote this original roundup of hyaluronic acid serums. Our Associate Product & Reviews Editor Jacqueline Saguin updated this story with our latest batch of expert-tested picks. She also interviewed dermatologists to answer the most searched questions about hyaluronic acid. Jacqueline also struggles with dry, sensitive skin and considers HA serums a crucial part of her skincare routine.

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