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Why You Need an Antioxidant Serum for Younger-Looking Skin

antioxidant serums

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We updated this article in December 2022 to add more expert commentary and information about each featured product, plus three new picks from Mary Kay, Olay and SkinCeuticals based on extensive testing done by the Good Housekeeping Institute.


You may have heard of antioxidants in your food — but they’re also a key part of an effective skincare routine for any skin type. Antioxidants, like vitamin C and resveratrol, play a crucial role in just how healthy, radiant and youthful your face looks both now and over time. “Every day, we are exposed to environmental factors that create free radicals in our skin, like pollution and ultraviolet rays,” explains Kavita Mariwalla, M.D., a dermatologist in West Islip, New York.

That’s where antioxidants, both in the form of ingested nutrients and in topical skincare products like face serums, come in. Applying skincare made with antioxidants an help neutralize the damaging effects of free radicals, says Dendy Engelman, M.D., a dermatologist in New York City — and, over time, help prevent and repair signs of skin aging, including hyperpigmentation, lines and wrinkles, inflammation and dullness.

In the Good Housekeeping Institute Beauty Lab, our scientists have a long history of testing face serums, including antioxidant and anti-aging serums, using scientific instruments to measure changes in skin over the time period of product use. Consumer testers also evaluate formulas on factors like the appearance of their skin before and after use, plus the product’s ease of use and cosmetic attributes. This data is then collated to find the best serums, including those with antioxidant properties.

Our top picks:

Not all antioxidant serums are created equal — some have bonus benefits like wrinkle smoothing, brightening, calming and more, depending on your skin type and needs. Here, read all about the best antioxidant serums you can buy and their benefits, including GH Beauty Lab top-tested formulas and Good Housekeeping Seal star picks, plus more on the top ingredients to look for.

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1

Best Overall Antioxidant Serum

Mary Kay

TimeWise Replenishing Serum C+E

Main ingredients Vitamins C and E
Additional benefits Firming, brightening, line smoothing
Size 1.5 oz.
2

Best Value Antioxidant Serum

RoC

Multi Correxion Revive + Glow Vitamin C Serum

Main ingredients Vitamin C, peptides
Additional benefits Brightens, evens skin tone
Size 1 oz.
3

Best Antioxidant Serum for Sensitive Skin

Eau Thermale Avène

A-Oxitive Antioxidant Defense Serum

Main ingredients Vitamins C and E, hyaluronic acid
Additional benefits Calming, softening
Size 1 oz.
4

Best Anti-Aging Antioxidant Serum

No7

Protect & Perfect Intense Advanced Serum

Main ingredients Vitamins C and E, peptides, retinol, hyaluronic acid
Additional benefits Smoothing, firming, pore minimizing
Size 1 oz.
5

Best Vitamin C Antioxidant Serum

SkinCeuticals

C E Ferulic

Main ingredients Vitamins C and E, ferulic acid
Additional benefits Brightening, anti-aging
Size 1 oz.
6

Best Antioxidant Serum for Acne-Prone Skin

SkinCeuticals

Phloretin CF Serum

Main ingredients Vitamin C, ferulic acid, phloretin
Additional benefits Evens skin tone
Size 1 oz.
7

Best Brightening Antioxidant Serum

Olay

Vitamin C + Peptide 24 Brightening Serum

Main ingredients Vitamin C, niacinamide
Additional benefits Reduces hyperpigmentation, anti-aging
Size 1.3 oz.
8

Best Antioxidant Serum for Oily Skin

SkinCeuticals

Silymarin CF

Main ingredients Vitamin C, salicylic acid
Additional benefits Purifying, smoothing
Size 1 oz.
9

Best Antioxidant Serum for Mature Skin

Mary Kay

Clinical Solutions C + Resveratrol Line-Reducer

Main ingredients Vitamin C, resveratrol, peptides
Additional benefits Anti-aging, line-smoothing
Size 0.5 oz.
10

Best Antioxidant Serum for Dark Spots

Olay

Tone Perfection Serum Vitamin B3 and Vitamin C

Main ingredients Vitamin C, niacinamide
Additional benefits Reduces hyperpigmentation, evens skin tone
Size 1.3 oz.
11

Best Dermatologist-Recommended Antioxidant Serum

SkinCeuticals

Metacell Renewal B3

Main ingredients Niacinamide, peptides
Additional benefits Line minimizing, brightening, firming
Size 1.7 oz.
12

Best Soothing Antioxidant Serum

Ren Clean Skincare

Evercalm Redness Relief Serum

Main ingredients Beta-carotene, vitamin E, hyaluronic acid
Additional benefits Calming, redness reducing
Size 1.02 oz.
13

Best Antioxidant Serum for Wrinkles

Olay

Regenerist Miracle Boost Concentrate

Main ingredients Niacinamide, peptides
Additional benefits Line smoothing
Size 1 oz.

How we test antioxidant serums

To determine the best serums, including those with antioxidants, GH Beauty Lab scientists first label-mask the products to eliminate bias, then distribute them to dozens of consumer testers, who use the formulas in their daily routines over a set time period between four and twelve weeks. In the Lab, analysts use the Visia Complexion Analyzer device to track changes in skin during the product’s use, including hyperpigmentation, lines and wrinkles, and pores.

When applicable, the Cutometer machine (below), which gauges skin laxity, is used to measure changes in firmness. Testers also report their feedback on skin’s look and feel during and after use, perceived changes in skin, and product attributes such as ease of use, scent, texture and absorption. Hundreds of data points are then tallied to find the best serums to target specific skincare issues.

What to look for when shopping for the best antioxidant serum

Although many ingredients are touted for their antioxidant effects, these are the most proven effective actives to seek out in face serums, according to Dr. Mariwalla:

✔️ Vitamin C, also known as ascorbic acid, known for reducing hyperpigmentation and evening skin tone. It’s the gold standard of antioxidants and is best for combination or dry skin, but steer clear if you’re oily or acne-prone, says Dr. Mariwalla, since “vitamin C does make some people break out.”
✔️ Niacinamide, a form of vitamin B3, has added benefits including brightening, minimizing wrinkles, and strengthening the skin barrier to lessen dryness and irritation. It’s generally well-tolerated by combination, dry and sensitive skin types, and is also great for acne-prone or oily skin as well.
✔️ Resveratrol, a polyphenol found in the skin of red grapes that has anti-aging effects, boosting firmness and smoothing. It’s great for combination, dry or sensitive skin.
✔️ Vitamin E, also known as tocopherol, which can soothe skin, making it ideal for combination, dry or sensitive skin.
✔️ Retinol, a vitamin A derivative, also a wrinkle smoothing and skin tone-evening active. Dr. Mariwalla recommends sticking with retinol if you’re acne- or oil-prone.
✔️ Green tea, a botanical that has anti-inflammatory effects, is best for combination, dry or sensitive skin.

What are the benefits of an antioxidant serum?

Antioxidant serums protect skin from damaging free radicals, helping prevent and repair signs of aging. “A free radical is a molecule with an unpaired electron, which means it is unstable and highly reactive,” says Dr. Mariwalla. “Free radicals on the skin are unstable atoms and as such are always seeking that extra electron from other cells to become stable,” she explains. “Once a free radical takes an electron from another molecule, that molecule becomes a free radical, setting off a chain reaction resulting in oxidative stress, which breaks down skin’s collagen and results in wrinkling and a sallow appearance. As these accumulate, the body is affected in the form of illness and accelerated aging.”

Like skin superheroes, antioxidants bind to free radicals and donate their electrons, stopping free radicals from stealing electrons from skin cells and causing damage. Over time, reduced free radical damage means less lines and wrinkles, hyperpigmentation and inflammation, which can lead to smoother and brighter skin.

When should you starting using an antioxidant serum?

Everyone’s skin is constantly exposed to free radicals, so an antioxidant serum can be beneficial at nearly any age, starting in the 20s. To incorporate an antioxidant serum into your skincare routine, apply it as your first step after washing your face in the morning, evening or both, “that way it [sits] directly on your skin,” Dr. Mariwalla advises.

If you choose to use your serum once daily, opt for the morning, since during the day skin is more exposed to environmental factors like UV light that can cause free radical damage. Note that antioxidant serums should be used in addition to a broad-spectrum face sunscreen, not in place of one.

Why trust Good Housekeeping?

April Franzino, the Beauty Director at Good Housekeeping, has over 15 years of experience researching, writing and editing skincare-related content, utilizing the expertise of GH Beauty Lab scientists and top industry professionals such as dermatologists and aestheticians. For this piece, she reported on the research behind, testing protocols for and results of the GH Beauty Lab’s testing of serums containing antioxidants. Franzino also interviewed dermatologist experts for insights into antioxidant serums as a category.

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